Title: In situ doxorubicin-CaP shell formation on amphiphilic gelatin-iron oxide core as a multifunctional drug delivery system with improved cytocompatibility, pH-responsive drug release and MR imaging
Authors: Li, W. -M.
Chen, S. -Y.
Liu, D. -M.
Department of Materials Science and Engineering
Keywords: Calcium phosphate;pH-sensitivity;Drug release;Amphiphilic gelatin;MR imaging
Issue Date: 1-Feb-2013
Abstract: An amphiphilic gelatin-iron oxide core/calcium phosphate shell (AGIO@CaP-DOX) nanoparticle was successfully synthesized as an efficient anti-cancer drug delivery system, where doxorubicin (DOX) as a model molecule was encapsulated by electrolytic co-deposition during CaP shell formation. The shell of CaP precipitate played a pivotal role, not only in acting as a drug depot, but also in rendering the drug release rate in a highly pH-dependent controlled manner. Together with MR imaging, highly biocompatible drug-carrying CaP shell and efficient cellular internalization, the AGIO@CaP-DOX nanoparticles developed in this study area promising multifunctional nanodevice for nanotherapeutic approaches. (C) 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
URI: http://dx.doi.org/10.1016/j.actbio.2012.09.023
ISSN: 1742-7061
DOI: 10.1016/j.actbio.2012.09.023
Volume: 9
Issue: 2
Begin Page: 5360
End Page: 5368
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