|Title:||In situ doxorubicin-CaP shell formation on amphiphilic gelatin-iron oxide core as a multifunctional drug delivery system with improved cytocompatibility, pH-responsive drug release and MR imaging|
|Authors:||Li, W. -M.|
Chen, S. -Y.
Liu, D. -M.
Department of Materials Science and Engineering
|Keywords:||Calcium phosphate;pH-sensitivity;Drug release;Amphiphilic gelatin;MR imaging|
|Abstract:||An amphiphilic gelatin-iron oxide core/calcium phosphate shell (AGIO@CaP-DOX) nanoparticle was successfully synthesized as an efficient anti-cancer drug delivery system, where doxorubicin (DOX) as a model molecule was encapsulated by electrolytic co-deposition during CaP shell formation. The shell of CaP precipitate played a pivotal role, not only in acting as a drug depot, but also in rendering the drug release rate in a highly pH-dependent controlled manner. Together with MR imaging, highly biocompatible drug-carrying CaP shell and efficient cellular internalization, the AGIO@CaP-DOX nanoparticles developed in this study area promising multifunctional nanodevice for nanotherapeutic approaches. (C) 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.|
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