|標題:||Highly selective fluorescent sensors for mercury(II) ions and their applications in living cell imaging|
Department of Applied Chemistry
|摘要:||Three new pyrene derivatives (MS1, MS2, and MS3) containing two triazole units exhibited fluorescence quenching in the presence of Hg2+ ions. Other metal ions Ag+, Ca2+, Cd2+,Co2+, Cu2+, Fe2+, Fe3+, K+, Mg2+, Mn2+, Na+, Ni2+, Pb2+, Rb+, and Zn2+ produced only minor changes in the fluorescence of MS1, MS2, and MS3. The binding ratio of the chemosensor-Hg2+ complexes was found to be 1:1 according to Job plot experiments. The association constants (K-a) of chemosensor-Hg2+ complexes were found to be 1.68x10(3) M-1 (MS1), 1.57x10(3) M-1 (MS2), and 1.52x10(3) M-1 (MS3), respectively. Moreover, fluorescence microscopy experiments showed that MS1 could be used as a fluorescent probe for detecting Hg2+ in living cells. (C) 2013 Elsevier Ltd. All rights reserved.|
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