標題: Peripheral neuropathology of the upper airway in obstructive sleep apnea syndrome
作者: Tsai, Yi-Ju
Ramar, Kannan
Liang, Yao-Jen
Chiu, Po-Han
Powell, Nelson
Chi, Chao-Yun
Lung, Tzu-Chen
Lin, Wesley Wen-Yang
Tseng, Po-Jung
Wu, Ming-Ying
Chien, Kuan-Chiao
Weaver, Edward M.
Lee, Fei-Peng
Lin, Chia-Mo
Chen, Kuang-Chao
Chiang, Rayleigh Ping-Ying
生物科技學系
Department of Biological Science and Technology
關鍵字: Obstructive sleep apnea syndrome;Neuropathology;Vibration trauma;Hypoxia;Inflammation;Upper airway surgery
公開日期: 1-四月-2013
摘要: Obstructive sleep apnea syndrome (OSAS) is a common sleep disorder that leads to significant morbidity and mortality without adequate treatment. Though much emphasis on the pathogenesis of OSAS has been placed on a narrow upper airway space and associated muscular factors, possible neuropathy of the upper airway has not been fully elucidated. Increasing peer reviewed evidence suggests involvement of neurologic lesions of the upper airway in OSAS patients. In this article, we review the etiology and pathophysiology of OSAS, the evidence and possible mechanisms leading to upper airway neuropathy, and the relationship between upper airway neuropathy and OSAS. Further studies should focus on the long term effects of the upper airway neuropathy as related to the duration and severity of snoring and or apnea, and also on the potential methods of prevention and management of the neuropathy in sleep disordered breathing. (C) 2012 Elsevier Ltd. All rights reserved.
URI: http://dx.doi.org/10.1016/j.smrv.2012.05.005
http://hdl.handle.net/11536/21161
ISSN: 1087-0792
DOI: 10.1016/j.smrv.2012.05.005
期刊: SLEEP MEDICINE REVIEWS
Volume: 17
Issue: 2
起始頁: 161
結束頁: 168
顯示於類別:期刊論文


文件中的檔案:

  1. 000315173800008.pdf