標題: Detecting small lung tumors in mouse models by refractive-index microradiology
作者: Chien, Chia-Chi
Zhang, Guilin
Hwu, Y.
Liu, Ping
Yue, Weisheng
Sun, Jianqi
Li, Yan
Xue, Hongjie
Xu, Lisa X.
Wang, Chang Hai
Chen, Nanyow
Lu, Chien Hung
Lee, Ting-Kuo
Yang, Yuh-Cheng
Lu, Yen-Ta
Ching, Yu-Tai
Shih, T. F.
Yang, P. C.
Je, J. H.
Margaritondo, G.
資訊工程學系
Department of Computer Science
關鍵字: Lung cancer;Synchrotron X-ray imaging;Real-time imaging
公開日期: 1-八月-2011
摘要: Refractive-index (phase-contrast) radiology was able to detect lung tumors less than 1 mm in live mice. Significant micromorphology differences were observed in the microradiographs between normal, inflamed, and lung cancer tissues. This was made possible by the high phase contrast and by the fast image taking that reduces the motion blur. The detection of cancer and inflammation areas by phase contrast microradiology and microtomography was validated by bioluminescence and histopathological analysis. The smallest tumor detected is less than 1 mm(3) with accuracy better than 1 x 10(-3) mm(3). This level of performance is currently suitable for animal studies, while further developments are required for clinical application.
URI: http://dx.doi.org/10.1007/s00216-011-5117-x
http://hdl.handle.net/11536/21094
ISSN: 1618-2642
DOI: 10.1007/s00216-011-5117-x
期刊: ANALYTICAL AND BIOANALYTICAL CHEMISTRY
Volume: 401
Issue: 3
起始頁: 827
結束頁: 835
顯示於類別:期刊論文


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