Title: Divergent ionic liquid supported synthesis of isolable guanidine linked quinoxalinone and benzodiamine
Authors: Chen, Li-Hsun
Xu, Zhan-Hui
Lin, Chun-Chung
Sun, Chung-Ming
Department of Applied Chemistry
Keywords: Ionic liquid support;Microwave synthesis;One-Bead-Two-Compound;Quinoxalinones
Issue Date: 6-Feb-2013
Abstract: Ionic liquid supported synthesis of guanidine linked piperazine, diazepane, and aminomethylpiperidine to difluoroquinoxalinones and difluoro benzodiamine was achieved by two regioisomeric products. They were isolated from one pot reduction and intramolecular cyclization to afford quinoxalinone ring system with traceless cleavage of ionic liquid support. Besides, the ionic-supported other isomer was further cleaved in methanol. All the reactions were carried out on an ionic liquid support under various conditions to deliver biologically relevant scaffolds with high purity and excellent yields. (C) 2012 Elsevier Ltd. All rights reserved.
URI: http://dx.doi.org/10.1016/j.tetlet.2012.11.012
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2012.11.012
Volume: 54
Issue: 6
Begin Page: 454
End Page: 458
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