標題: Divergent ionic liquid supported synthesis of isolable guanidine linked quinoxalinone and benzodiamine
作者: Chen, Li-Hsun
Xu, Zhan-Hui
Lin, Chun-Chung
Sun, Chung-Ming
應用化學系
Department of Applied Chemistry
關鍵字: Ionic liquid support;Microwave synthesis;One-Bead-Two-Compound;Quinoxalinones
公開日期: 6-二月-2013
摘要: Ionic liquid supported synthesis of guanidine linked piperazine, diazepane, and aminomethylpiperidine to difluoroquinoxalinones and difluoro benzodiamine was achieved by two regioisomeric products. They were isolated from one pot reduction and intramolecular cyclization to afford quinoxalinone ring system with traceless cleavage of ionic liquid support. Besides, the ionic-supported other isomer was further cleaved in methanol. All the reactions were carried out on an ionic liquid support under various conditions to deliver biologically relevant scaffolds with high purity and excellent yields. (C) 2012 Elsevier Ltd. All rights reserved.
URI: http://dx.doi.org/10.1016/j.tetlet.2012.11.012
http://hdl.handle.net/11536/21017
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2012.11.012
期刊: TETRAHEDRON LETTERS
Volume: 54
Issue: 6
起始頁: 454
結束頁: 458
顯示於類別:期刊論文


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  1. 000314388300002.pdf