標題: PHOTOCYCLOADDITION OF FUMARONITRILE TO ADAMANTAN-2-ONES AND MODIFICATION OF FACE SELECTIVITY BY INCLUSION IN BETA-CYCLODEXTRIN AND ITS DERIVATIVES
作者: CHUNG, WS
WANG, NJ
LIU, YD
LEU, YJ
CHIANG, MY
應用化學系
Department of Applied Chemistry
公開日期: 1-二月-1995
摘要: The face selectivity in 5-substituted-adamantan-2-ones (1-Xs) can be dramatically reversed by means of inclusion into beta-cyclodextrin (beta-CD) and its heptakis(6-O-hydroxypropyl), heptakis(6-O-acetyl), heptakis(2,3,6-tri-O-methyl) and heptakis(2,3,6-tri-O-acetyl) derivatives. The 5-substituents varied from fluoro, chloro, bromo, phenyl to trimethylsilyl, and face selectivities of the oxetane formation have been found to vary with the sizes of 5-substituents and cavities of beta-CDs. A 98:2 face selectivity was achieved when 1-SiMe(3) was used as a probe. The effect observed is interpreted by assuming that the carbonyl pi-face syn to the bulky 5-substituent is partially locked by the torus of the host due to complexation of 1-X and CD. Information obtained from H-1 NMR titration and X-ray powder diffraction study on the inclusion complex is consistent with the above explanation. X-ray single-crystal structure was used to determine the oxetane structure of anti-2-SiMe(3).
URI: http://dx.doi.org/10.1039/p29950000307
http://hdl.handle.net/11536/2097
ISSN: 0300-9580
DOI: 10.1039/p29950000307
期刊: JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2
Volume: 
Issue: 2
起始頁: 307
結束頁: 313
顯示於類別:期刊論文


文件中的檔案:

  1. A1995QF78700019.pdf