標題: Facile Synthesis of Radial-Like Macroporous Superparamagnetic Chitosan Spheres with In-Situ Co-Precipitation and Gelation of Ferro-Gels
作者: Yang, Chih-Hui
Wang, Chih-Yu
Huang, Keng-Shiang
Yeh, Chen-Sheng
Wang, Andrew H. -J.
Wang, Wei-Ting
Lin, Ming-Yu
分子醫學與生物工程研究所
Institute of Molecular Medicine and Bioengineering
公開日期: 30-十一月-2012
摘要: Macroporous chitosan spheres encapsulating superparamagnetic iron oxide nanoparticles were synthesized by a facile and effective one-step fabrication process. Ferro-gels containing ferrous cations, ferric cations and chitosan were dropped into a sodium hydroxide solution through a syringe pump. In addition, a sodium hydroxide solution was employed for both gelation (chitosan) and co-precipitation (ferrous cations and ferric cations) of the ferro-gels. The results showed that the in-situ co-precipitation of ferro-ions gave rise to a radial morphology with non-spheroid macro pores (large cavities) inside the chitosan spheres. The particle size of iron oxide can be adjusted from 2.5 nm to 5.4 nm by tuning the concentration of the sodium hydroxide solution. Using Fourier Transform Infrared Spectroscopy and X-ray diffraction spectra, the synthesized nanoparticles were illustrated as Fe3O4 nanoparticles. In addition, the prepared macroporous chitosan spheres presented a super-paramagnetic behaviour at room temperature with a saturation magnetization value as high as ca. 18 emu/g. The cytotoxicity was estimated using cell viability by incubating doses (0 similar to 1000 mu g/mL) of the macroporous chitosan spheres. The result showed good viability (above 80%) with alginate chitosan particles below 1000 mu g/mL, indicating that macroporous chitosan spheres were potentially useful for biomedical applications in the future.
URI: http://dx.doi.org/10.1371/journal.pone.0049329
http://hdl.handle.net/11536/20867
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0049329
期刊: PLOS ONE
Volume: 7
Issue: 11
結束頁: 
顯示於類別:期刊論文


文件中的檔案:

  1. 000312376100016.pdf