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dc.contributor.authorChiu, Yi-Yuanen_US
dc.contributor.authorLin, Chih-Taen_US
dc.contributor.authorHuang, Jhang-Weien_US
dc.contributor.authorHsu, Kai-Chengen_US
dc.contributor.authorTseng, Jen-Huen_US
dc.contributor.authorYou, Syuan-Renen_US
dc.contributor.authorYang, Jinn-Moonen_US
dc.date.accessioned2014-12-08T15:28:44Z-
dc.date.available2014-12-08T15:28:44Z-
dc.date.issued2013-01-01en_US
dc.identifier.issn0305-1048en_US
dc.identifier.urihttp://dx.doi.org/10.1093/nar/gks1218en_US
dc.identifier.urihttp://hdl.handle.net/11536/20796-
dc.description.abstractKinases play central roles in signaling pathways and are promising therapeutic targets for many diseases. Designing selective kinase inhibitors is an emergent and challenging task, because kinases share an evolutionary conserved ATP-binding site. KIDFamMap (http://gemdock.life.nctu.edu.tw/KIDFamMap/) is the first database to explore kinase-inhibitor families (KIFs) and kinase-inhibitor-disease (KID) relationships for kinase inhibitor selectivity and mechanisms. This database includes 1208 KIFs, 962 KIDs, 55 603 kinase-inhibitor interactions (KIIs), 35 788 kinase inhibitors, 399 human protein kinases, 339 diseases and 638 disease allelic variants. Here, a KIF can be defined as follows: (i) the kinases in the KIF with significant sequence similarity, (ii) the inhibitors in the KIF with significant topology similarity and (iii) the KIIs in the KIF with significant interaction similarity. The KIIs within a KIF are often conserved on some consensus KIDFamMap anchors, which represent conserved interactions between the kinase subsites and consensus moieties of their inhibitors. Our experimental results reveal that the members of a KIF often possess similar inhibition profiles. The KIDFamMap anchors can reflect kinase conformations types, kinase functions and kinase inhibitor selectivity. We believe that KIDFamMap provides biological insights into kinase inhibitor selectivity and binding mechanisms.en_US
dc.language.isoen_USen_US
dc.titleKIDFamMap: a database of kinase-inhibitor-disease family maps for kinase inhibitor selectivity and binding mechanismsen_US
dc.typeArticleen_US
dc.identifier.doi10.1093/nar/gks1218en_US
dc.identifier.journalNUCLEIC ACIDS RESEARCHen_US
dc.citation.volume41en_US
dc.citation.issueD1en_US
dc.citation.spageD430en_US
dc.citation.epageD440en_US
dc.contributor.department生物科技學系zh_TW
dc.contributor.department生物資訊及系統生物研究所zh_TW
dc.contributor.departmentDepartment of Biological Science and Technologyen_US
dc.contributor.departmentInstitude of Bioinformatics and Systems Biologyen_US
dc.identifier.wosnumberWOS:000312893300061-
dc.citation.woscount2-
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