標題: Association Between Chronic Hepatitis C Virus Infection and Bone Mineral Density
作者: Lin, Jung-Chun
Hsieh, Tsai-Yuan
Wu, Chia-Chun
Chen, Peng-Jen
Chueh, Tung-Hung
Chang, Wei-Kuo
Chu, Heng-Cheng
統計學研究所
Institute of Statistics
關鍵字: Bone mineral density;Osteodystrophy;Osteoporosis;Viral hepatitis
公開日期: 1-Dec-2012
摘要: Whether chronic hepatitis C virus (HCV) infection is a risk factor for the development of bone disease has long been controversial. For this reason, chronic HCV-infected participants (n = 69) were recruited into a prospective cohort study and underwent dual-energy X-ray absorptiometry for determination of bone mineral density (BMD). Fibrosis staging was evaluated according to the noninvasive index FIB-4. T scores at the femoral neck and lumbar spine were used as the primary outcome variables to assess the association between degree of liver disease and BMD. The study cohort was 41 % male with a mean age of 53.6 years. The mean BMD, Z score, and T score values of lumbar spine in chronic hepatitis C (CHC) patients were significantly lower than those in healthy controls (p < 0.001). The rate of osteoporosis for CHC patients aged 45-54 years was significantly higher than that of the control group (p = 0.011). Bone alkaline phosphatase and C-terminal cross-linking telopeptide of type I collagen levels were also significantly higher in CHC patients with reduced BMD. Patients with more advanced liver fibrosis had significantly lower BMD. In conclusion, reduced BMD is common in this population of chronic HCV-infected patients and associated with liver disease severity. This extrahepatic manifestation is probably secondary to increased bone turnover in osteodystrophy pathogenesis.
URI: http://dx.doi.org/10.1007/s00223-012-9653-y
http://hdl.handle.net/11536/20602
ISSN: 0171-967X
DOI: 10.1007/s00223-012-9653-y
期刊: CALCIFIED TISSUE INTERNATIONAL
Volume: 91
Issue: 6
起始頁: 423
結束頁: 429
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