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dc.contributor.authorChang, Li-Hsunen_US
dc.contributor.authorChen, Peilongen_US
dc.contributor.authorLien, Mong-Tingen_US
dc.contributor.authorHo, Yu-Hueien_US
dc.contributor.authorLin, Chiao-Mingen_US
dc.contributor.authorPan, Yi-Tingen_US
dc.contributor.authorWei, Shu-Yien_US
dc.contributor.authorHsu, Jui-Chouen_US
dc.date.accessioned2014-12-08T15:27:43Z-
dc.date.available2014-12-08T15:27:43Z-
dc.date.issued2011-09-01en_US
dc.identifier.issn0950-1991en_US
dc.identifier.urihttp://dx.doi.org/10.1242/dev.062257en_US
dc.identifier.urihttp://hdl.handle.net/11536/19971-
dc.description.abstractCell sorting involves the segregation of two cell populations into 'immiscible' adjacent tissues with smooth borders. Echinoid (Ed), a nectin ortholog, is an adherens junction protein in Drosophila, and cells mutant for ed sort out from the surrounding wild-type cells. However, it remains unknown which factors trigger cell sorting. Here, we dissect the sequence of this process and find that cell sorting occurs when differential expression of Ed triggers the assembly of actomyosin cable. Conversely, Ed-mediated cell sorting can be rescued by recruitment of Ed, via homophilic or heterophilic interactions, to the wild-type cell side of the clonal interface, even when differential Ed expression persists. We found, unexpectedly, that when actomyosin cable was largely absent, differential adhesion was sufficient to cause limited cell segregation but with a jagged tissue border (imperfect sorting). We propose that Ed-mediated cell sorting is driven both by differential Ed adhesion that induces cell segregation with a jagged border and by actomyosin cable assembly at the interface that smoothens this border.en_US
dc.language.isoen_USen_US
dc.subjectEchinoiden_US
dc.subjectDifferential adhesionen_US
dc.subjectDifferential expressionen_US
dc.subjectCell sortingen_US
dc.subjectActomyosinen_US
dc.subjectDrosophilaen_US
dc.titleDifferential adhesion and actomyosin cable collaborate to drive Echinoid-mediated cell sortingen_US
dc.typeArticleen_US
dc.identifier.doi10.1242/dev.062257en_US
dc.identifier.journalDEVELOPMENTen_US
dc.citation.volume138en_US
dc.citation.issue17en_US
dc.citation.spage3803en_US
dc.citation.epage3812en_US
dc.contributor.department生物科技學系zh_TW
dc.contributor.departmentDepartment of Biological Science and Technologyen_US
dc.identifier.wosnumberWOS:000293687700019-
dc.citation.woscount10-
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