標題: Novel ionic liquid supported-multicomponent reaction toward chimeric bis-heterocycles
作者: Chen, Chih-Hau
Chen, Chan-Yu
Lin, Po-Tsung
Sun, Chung-Ming
應用化學系
Department of Applied Chemistry
關鍵字: Multicomponent reaction;MCR;Ionic liquid support;Chimeric scaffolds;[1,5]Sigmatropic rearrangement;Benzimidazole-linked dihydropyrimidine
公開日期: 1-八月-2012
摘要: A novel multicomponent reaction between IL-anchored 2-aminobenzoimidazoles, aldehydes, and electron-deficient dienophiles has been explored. The strategy was utilized to develop a rapid parallel synthesis for novel bis-heterocyclic skeleton of benzimidazole-linked dihydropyrimidine on an ionic liquid support. This multicomponent reaction is compatible with a wide range of substrates and furnishes the new chimeric scaffolds with high purity and excellent yields. Use of the ionic liquid as a soluble support facilitates purification by simple precipitation along with advantages like high loading capacity, homogeneous reaction conditions, and monitoring of the reaction progress by conventional NMR spectroscopy.
URI: http://dx.doi.org/10.1007/s11030-012-9383-0
http://hdl.handle.net/11536/16916
ISSN: 1381-1991
DOI: 10.1007/s11030-012-9383-0
期刊: MOLECULAR DIVERSITY
Volume: 16
Issue: 3
起始頁: 503
結束頁: 512
顯示於類別:期刊論文


文件中的檔案:

  1. 000308555600008.pdf