標題: Exploring a sulfone linker utilizing trimethyl aluminum as a cleavage reagent: solid-phase synthesis of sulfonamides and ureas
作者: Chung, Tsai-Wen
Chen, Chih-Hau
Lin, Chu-Chung
Wu, Hsien-Jen
Sun, Chung-Ming
Chung, Wen-Sheng
應用化學系
Department of Applied Chemistry
關鍵字: Trimethyl aluminum;Traceless;Solid-phase synthesis;Sulfone linker;Sulfinate-functionalized resin;Sulfonamides;Ureas
公開日期: 1-Aug-2012
摘要: A novel and efficient cleavage reagent, trimethyl aluminum, for traceless sulfinate-functionalized resin has been developed. The synthesis of sulfonamide and urea derivatives via a traceless solid-phase sulfone linker strategy through six synthetic steps comprising utilization of trimethyl aluminum as a novel cleavage reagent was also established. An insight of the plausible mechanism of the cleavage reaction was discussed.
URI: http://dx.doi.org/10.1007/s11030-012-9380-3
http://hdl.handle.net/11536/16915
ISSN: 1381-1991
DOI: 10.1007/s11030-012-9380-3
期刊: MOLECULAR DIVERSITY
Volume: 16
Issue: 3
起始頁: 463
結束頁: 476
Appears in Collections:Articles


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