標題: Design and characterization of a novel amphiphilic chitosan nanocapsule-based thermo-gelling biogel with sustained in vivo release of the hydrophilic anti-epilepsy drug ethosuximide
作者: Hsiao, Meng-Hsuan
Larsson, Mikael
Larsson, Anette
Evenbratt, Hanne
Chen, Ying-Yu
Chen, You-Yin
Liu, Dean-Mo
材料科學與工程學系
Department of Materials Science and Engineering
關鍵字: Amphiphilic chitosan;Drug delivery;Nano capsules;Thermo responsive;In vivo
公開日期: 10-Aug-2012
摘要: Thermo-gelling injectable nanogels, with no burst release of loaded drug, were prepared by a simple route by combining self assembled nanocapsules of amphiphilically modified chitosan with glycerophosphate di-sodium salt and glycerol. The potential as a depot drug delivery system was demonstrated in vivo through the therapeutic effect of ethosuximide (ESM) loaded nanogels, suppressing spike wave discharges (SWDs) in Long Evan rat model. Simultaneously clearance of gels from the site of administration was monitored non-invasively using MRI. The gel structure was characterized using TEM and SEM, confirming the gels to be an assembly of nanocapsules and using two-photon microscopy to visualize the network structure. In vitro drug release studies using ESM revealed that the nanogels exhibited extended, mostly Fickian release. Finally, all investigated formulations displayed excellent cytotoxicity data determined by MTT assay using human retinal pigmented epithelium cells. All presented properties are highly desirable for injectable depot gels for drug delivery. (c) 2012 Elsevier B.V. All rights reserved.
URI: http://dx.doi.org/10.1016/j.jconrel.2012.05.038
http://hdl.handle.net/11536/16906
ISSN: 0168-3659
DOI: 10.1016/j.jconrel.2012.05.038
期刊: JOURNAL OF CONTROLLED RELEASE
Volume: 161
Issue: 3
起始頁: 942
結束頁: 948
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