Title: VIP DB - A viral protein domain usage and distribution database
Authors: Chen, Ting-Wen
Gan, Richie Ruei-Chi
Wu, Timothy H.
Lin, Wen-Chang
Tang, Petrus
Department of Biological Science and Technology
Keywords: Protein domain;Domain-domain interaction;Viral protein interaction;Protein annotation
Issue Date: 1-Sep-2012
Abstract: During the viral infection and replication processes, viral proteins are highly regulated and may interact with host proteins. However, the functions and interaction partners of many viral proteins have yet to be explored. Here, we compiled a Viral Protein domain DataBase (VIP DB) to associate viral proteins with putative functions and interaction partners. We systematically assign domains and infer the functions of proteins and their protein interaction partners from their domain annotations. A total of 2,322 unique domains that were identified from 2,404 viruses are used as a starting point to correlate GO classification, KEGG metabolic pathway annotation and domain-domain interactions. Of the unique domains, 42.7% have GO records, 39.6% have at least one domain-domain interaction record and 26.3% can also be found in either mammals or plants. This database provides a resource to help virologists identify potential roles for viral protein. All of the information is available at http://vipdb.cgu.edu.tw. (C) 2012 Elsevier Inc. All rights reserved.
URI: http://dx.doi.org/10.1016/j.ygeno.2012.06.008
ISSN: 0888-7543
DOI: 10.1016/j.ygeno.2012.06.008
Volume: 100
Issue: 3
Begin Page: 149
End Page: 156
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