Title: A computerized system of nail-fold capillaroscopy for dry eye disease diagnosis
Authors: Hou, Mark C.
Huang, Sheng-Chieh
Wang, Hui-Min
Tseng, Cheng-Lung
Lo, Lun-Chien
Chen, Ying-Ling
Department of Electrical and Computer Engineering
Keywords: Nail-fold capillaroscopy;Image processing;Dry eye disease
Issue Date: 1-Dec-2012
Abstract: Nail-fold Capillaroscopy is a convenient and non-invasive tool to evaluate peripheral circulation. Rheumatic diseases such as Raynaud's disease and systemic sclerosis are investigated mostly by nail-fold capillaroscopy. However, it has not been used popularly due to the lack of golden standard in both measurement procedure and objective quantity analysis. This study proposes a computerized system of nail-fold capillaroscopy (CNC). CNC includes standard measurement procedures and three criterions of microcirculation which are capillary density, capillary width and blood flow velocity. CNC is applied to the images of 36 normal subjects and seven patients of dry eye disease (DED). We found density and width of afferent capillary were the better parameters to identify DED (p < 0.05). CNC could be a good auxiliary diagnostic tool for DED.
URI: http://dx.doi.org/10.1007/s11045-012-0177-4
ISSN: 0923-6082
DOI: 10.1007/s11045-012-0177-4
Volume: 23
Issue: 4
Begin Page: 515
End Page: 524
Appears in Collections:Articles

Files in This Item:

  1. 000306800600007.pdf