標題: X-ray microscopy and tomography detect the accumulation of bare and PEG-coated gold nanoparticles in normal and tumor mouse tissues
作者: Chien, C-C.
Cheng, C-C.
Chen, H. H.
Hwu, Y.
Chu, Y. S.
Petibois, C.
Chen, A.
Ching, Y-T.
Margaritondo, G.
資訊工程學系
Department of Computer Science
關鍵字: High resolution X-ray microscopy;Nanoparticles;3D tissue imaging
公開日期: 1-Sep-2012
摘要: "We demonstrate that, with appropriate staining, high-resolution X-ray microscopy can image complicated tissue structures-cerebellum and liver-and resolve large or small amounts of Au nanoparticles in these tissues. Specifically, images of tumor tissue reveal high concentrations of accumulated Au nanoparticles. PEG (poly(ethylene glycol)) coating is quite effective in enhancing this accumulation and significantly modifies the mechanism of uptake by reticuloendothelial system (RES) organs."
URI: http://hdl.handle.net/11536/16707
ISSN: 1618-2642
期刊: ANALYTICAL AND BIOANALYTICAL CHEMISTRY
Volume: 404
Issue: 5
結束頁: 1287
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