標題: Determinants of Exon-Level Evolutionary Rates in Arabidopsis Species
作者: Wu, Gideon C. -T.
Chen, Feng-Chi
生物科技學系
Department of Biological Science and Technology
關鍵字: exonic evolutionary rates;nonsynonymous substitution rate;synonymous substitution rate;principal component regression;Arabidopsis thaliana
公開日期: 2012
摘要: "What causes the variations in evolutionary rates is fundamental to molecular evolution. However, in plants, the causes of within-gene evolutionary rate variations remain underexplored. Here we use the principal component regression to examine the contributions of eleven exon features to the within-gene variations in nonsynonymous substitution rate (d(N)), synonymous substitution rate (d(S)), and the d(N)/d(S) ratio in Arabidopsis species. We demonstrate that exon features related to protein structural-functional constraints and mRNA splicing account for the largest proportions of within-gene variations in d(N)/d(S) and d(N). Meanwhile, for d(S), a combination of expression level, exon length, and structural-functional features explains the largest proportion of within-gene variances. Our results suggest that the determinants of within-gene variations differ from those of between-gene variations in evolutionary rates. Furthermore, the relative importance of different exon features also differs between plants and animals. Our study thus may shed a new light on the evolution of plant genes."
URI: http://hdl.handle.net/11536/16676
ISSN: 1176-9343
期刊: EVOLUTIONARY BIOINFORMATICS
Volume: 8
結束頁: 389
顯示於類別:期刊論文


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