Title: Enhancement of anti-murine colon cancer immunity by fusion of a SARS fragment to a low-immunogenic carcinoembryonic antigen
Authors: Lin, Chen-Si
Kao, Shih-Han
Chen, Yu-Cheng
Li, Chi-Han
Hsieh, Yuan-Ting
Yang, Shang-Chih
Wu, Chang-Jer
Lee, Ru-Ping
Liao, Kuang-Wen
Department of Biological Science and Technology
Keywords: immunotherapy;tumor-derived peptide;tumor vaccine;low-immunogenicity
Issue Date: 1-Jan-1970
Abstract: "Background: It is widely understood that tumor cells express tumor-associated antigens (TAAs), of which many are usually in low immunogenicity; for example, carcinoembryonic antigen (CEA) is specifically expressed on human colon cancer cells and is viewed as a low-immunogenic TAA. How to activate host immunity against specific TAAs and to suppress tumor growth therefore becomes important in cancer therapy development. Results: To enhance the immune efficiency of CEA in mice that received, we fused a partial CEA gene with exogenous SARS-CoV fragments. Oral vaccination of an attenuated Salmonella typhimurium strain transformed with plasmids encoding CEA-SARS-CoV fusion gene into BALB/c mice elicited significant increases in TNF-alpha and IL-10 in the serum. In addition, a smaller tumor volume was observed in CT26/CEA-bearing mice who received CEA-SARS-CoV gene therapy in comparison with those administered CEA alone. Conclusion: The administration of fusing CEA-SARS-CoV fragments may provide a promising strategy for strengthening the anti-tumor efficacy against low-immunogenic endogenous tumor antigens."
URI: http://dx.doi.org/2
ISSN: 1480-9222
DOI: 2
Volume: 14
End Page: 
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