標題: CPred: a web server for predicting viable circular permutations in proteins
作者: Lo, Wei-Cheng
Wang, Li-Fen
Liu, Yen-Yi
Dai, Tian
Hwang, Jenn-Kang
Lyu, Ping-Chiang
生物科技學系
Department of Biological Science and Technology
公開日期: 1-七月-2012
摘要: "Circular permutation (CP) is a protein structural rearrangement phenomenon, through which nature allows structural homologs to have different locations of termini and thus varied activities, stabilities and functional properties. It can be applied in many fields of protein research and bioengineering. The limitation of applying CP lies in its technical complexity, high cost and uncertainty of the viability of the resulting protein variants. Not every position in a protein can be used to create a viable circular permutant, but there is still a lack of practical computational tools for evaluating the positional feasibility of CP before costly experiments are carried out. We have previously designed a comprehensive method for predicting viable CP cleavage sites in proteins. In this work, we implement that method into an efficient and user-friendly web server named CPred (CP site predictor), which is supposed to be helpful to promote fundamental researches and biotechnological applications of CP. The CPred is accessible at http://sarst.life.nthu.edu.tw/CPred."
URI: http://hdl.handle.net/11536/16640
ISSN: 0305-1048
期刊: NUCLEIC ACIDS RESEARCH
Volume: 40
Issue: W1
結束頁: W232
顯示於類別:期刊論文


文件中的檔案:

  1. 000306670900038.pdf