標題: pKNOT v.2: the protein KNOT web server
作者: Lai, Yan-Long
Chen, Chih-Chieh
Hwang, Jenn-Kang
生物資訊及系統生物研究所
Institude of Bioinformatics and Systems Biology
公開日期: 1-七月-2012
摘要: "Knotted proteins have recently received lots of attention due to their interesting topological novelty as well as its puzzling folding mechanisms. We previously published a pKNOT server, which provides a structural database of knotted proteins, analysis tools for detecting and analyzing knotted regions from structures as well as a Java-based 3D graphics viewer for visualizing knotted structures. However, there lacks a convenient platform performing similar tasks directly from 'protein sequences'. In the current version of the web server, referred to as pKNOT v.2, we implement a homology modeling tool such that the server can now accept protein sequences in addition to 3D structures or Protein Data Bank (PDB) IDs and return knot analysis. In addition, we have updated the database of knotted proteins from the current PDB with a combination of automatic and manual procedure. We believe that the updated pKNOT server with its extended functionalities will provide better service to biologists interested in the research of knotted proteins. The pKNOT v.2 is available from http://pknot.life.nctu.edu.tw/."
URI: http://hdl.handle.net/11536/16637
ISSN: 0305-1048
期刊: NUCLEIC ACIDS RESEARCH
Volume: 40
Issue: W1
結束頁: W228
顯示於類別:期刊論文


文件中的檔案:

  1. 000306670900037.pdf