標題: Microwave-assisted synthesis of highly functionalized guanidines on soluble polymer support
作者: Chen, Chih-Hau
Tung, Chieh-Li
Sun, Chung-Ming
應用化學系
Department of Applied Chemistry
關鍵字: Carbamate-protected guanidines;Microwave irradiation;Soluble polymer support
公開日期: 1-一月-1970
摘要: "An efficient method for the N,N'-di(Boc)-protected guanidines containing piperazine and homopiperazine scaffolds has been developed under multi-step microwave irradiation. Followed by alkylation of carbamate-protected guanidines with various alkyl halides is also explored. This protocol proceeds via deprotonation of the acidic N-carbamate hydrogen of the guanidine by sodium hydride on soluble polymer support. In this manner, highly functionalized guanidines were obtained after cleavage from the support. The reaction is tolerant of a wide range of functional groups on both the alkyl halide and guanidine components. In addition, the reaction is sufficiently simple workup by precipitation in each step to yield the substituted guanidines in high purity. In conjunction with microwave irradiation and soluble polymer support, this method provides an efficient route to access highly functionalized guanidines. (C) 2012 Elsevier Ltd. All rights reserved."
URI: http://hdl.handle.net/11536/16611
ISSN: 0040-4039
期刊: TETRAHEDRON LETTERS
Volume: 53
Issue: 31
結束頁: 3959
顯示於類別:期刊論文