標題: Design and Synthesis of New Biprivileged Molecular Scaffolds: Indolo-Fused Benzodiazepinyl/quinoxalinyl benzimidazoles
作者: Barve, Indrajeet J.
Chen, Chan-Yu
Salunke, Deepak B.
Chung, Wen-Sheng
Sun, Chung-Ming
應用化學系
Department of Applied Chemistry
關鍵字: drug discovery;heterocycles;Pictet-Spengler-type reactions;privileged structures;synthesis design
公開日期: 1-六月-2012
摘要: The present article describes the design and synthesis of new biprivileged molecular scaffolds with diverse structural features. Commercially available, simple heterocyclic building blocks such as 4-fluoro-3-nitrobenzoic acid, 2-chloro-3-nitrobenzoic acid, and indoline were utilized for the synthesis of the novel heterocycles. PictetSpengler-type condensation was used as a key step to construct tetracyclic indolo-benzodiazepines and indolo-quinoxalines linked with substituted benzimidazoles. Analysis of single crystals of representative compounds showed that these molecular skeletons have the potential to present various substituents with distinct three-dimensional orientations.
URI: http://hdl.handle.net/11536/16516
ISSN: 1861-4728
期刊: CHEMISTRY-AN ASIAN JOURNAL
Volume: 7
Issue: 7
結束頁: 1684
顯示於類別:期刊論文


文件中的檔案:

  1. 000305239500032.pdf