|標題:||Design and Synthesis of New Biprivileged Molecular Scaffolds: Indolo-Fused Benzodiazepinyl/quinoxalinyl benzimidazoles|
|作者:||Barve, Indrajeet J.|
Salunke, Deepak B.
Department of Applied Chemistry
|關鍵字:||drug discovery;heterocycles;Pictet-Spengler-type reactions;privileged structures;synthesis design|
|摘要:||The present article describes the design and synthesis of new biprivileged molecular scaffolds with diverse structural features. Commercially available, simple heterocyclic building blocks such as 4-fluoro-3-nitrobenzoic acid, 2-chloro-3-nitrobenzoic acid, and indoline were utilized for the synthesis of the novel heterocycles. PictetSpengler-type condensation was used as a key step to construct tetracyclic indolo-benzodiazepines and indolo-quinoxalines linked with substituted benzimidazoles. Analysis of single crystals of representative compounds showed that these molecular skeletons have the potential to present various substituents with distinct three-dimensional orientations.|
|期刊:||CHEMISTRY-AN ASIAN JOURNAL|