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dc.contributor.authorLiao, Lun-Deen_US
dc.contributor.authorChen, You-Yinen_US
dc.contributor.authorLin, Chin-Tengen_US
dc.contributor.authorChang, Jyh-Yeongen_US
dc.contributor.authorLi, Meng-Linen_US
dc.date.accessioned2014-12-08T15:23:24Z-
dc.date.available2014-12-08T15:23:24Z-
dc.date.issued2012en_US
dc.identifier.isbn978-0-8194-8866-4en_US
dc.identifier.issn0277-786Xen_US
dc.identifier.urihttp://hdl.handle.net/11536/16393-
dc.identifier.urihttp://dx.doi.org/822334en_US
dc.description.abstractThe specificity of the hemodynamic response function (HRF) is determined spatially by the vascular architecture and temporally by the evolution of hemodynamic changes. Here, we used functional photoacoustic microscopy (fPAM) to investigate the spatiotemporal evolution of the HRFs of hemoglobin concentration (HbT), cerebral blood volume (CBV) and hemoglobin oxygen saturation (SO2) in single cerebral vessels to rat left-forepaw stimulation. The HRF changes in specific cerebral vessels responding to different stimulation intensities and durations were bilaterally imaged with 36 x 65-mu m spatial resolution. Various electrical stimulations were applied with stimulation intensities at 1, 2, 6 and 10-mA combined with 5-s and 15-s stimulation durations, respectively. Our main findings were as follows: 1) the functional HbT and SO2 increased sub-linearly with increasing stimulus intensities and 2) the results suggested that the CBV changes are more linearly correlated with arterioles than HbT and SO2 within a limited dynamic range of stimulation intensities and duration. The findings in this study indicate that the regulation of hemodynamic changes in single cerebral vessels can be reliable studied by the fPAM technique without the use of contrast agents.en_US
dc.language.isoen_USen_US
dc.subjecthemodynamic response functionen_US
dc.subjectfunctional imagingen_US
dc.subjectphotoacoustic microscopyen_US
dc.subjectelectrical stimulationen_US
dc.subjecthemoglobin oxygenationen_US
dc.titleFunctional photoacoustic micro-imaging of rat cerebral hemodynamic response function in single vessels during forepaw electrical stimulationen_US
dc.typeProceedings Paperen_US
dc.identifier.doi822334en_US
dc.identifier.journalPHOTONS PLUS ULTRASOUND: IMAGING AND SENSING 2012en_US
dc.citation.volume8223en_US
dc.contributor.department電機工程學系zh_TW
dc.contributor.departmentDepartment of Electrical and Computer Engineeringen_US
dc.identifier.wosnumberWOS:000305073300086-
Appears in Collections:Conferences Paper


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