Title: Microfluidic Synthesis of Microfibers for Magnetic-Responsive Controlled Drug Release and Cell Culture
Authors: Lin, Yung-Sheng
Huang, Keng-Shiang
Yang, Chih-Hui
Wang, Chih-Yu
Yang, Yuh-Shyong
Hsu, Hsiang-Chen
Liao, Yu-Ju
Tsai, Chia-Wen
Department of Biological Science and Technology
Issue Date: 28-Mar-2012
Abstract: This study demonstrated the fabrication of alginate microfibers using a modular microfluidic system for magnetic-responsive controlled drug release and cell culture. A novel two-dimensional fluid-focusing technique with multi-inlets and junctions was used to spatiotemporally control the continuous laminar flow of alginate solutions. The diameter of the manufactured microfibers, which ranged from 211 mm to 364 mm, could be well controlled by changing the flow rate of the continuous phase. While the model drug, diclofenac, was encapsulated into microfibers, the drug release profile exhibited the characteristic of a proper and steady release. Furthermore, the diclofenac release kinetics from the magnetic iron oxide-loaded microfibers could be controlled externally, allowing for a rapid drug release by applying a magnetic force. In addition, the successful culture of glioblastoma multiforme cells in the microfibers demonstrated a good structural integrity and environment to grow cells that could be applied in drug screening for targeting cancer cells. The proposed microfluidic system has the advantages of ease of fabrication, simplicity, and a fast and low-cost process that is capable of generating functional microfibers with the potential for biomedical applications, such as drug controlled release and cell culture.
URI: http://dx.doi.org/e33184
ISSN: 1932-6203
DOI: e33184
Journal: PLOS ONE
Volume: 7
Issue: 3
End Page: 
Appears in Collections:Articles

Files in This Item:

  1. 000304489000017.pdf