Title: Light Fluorous-Tagged Traceless One-Pot Synthesis of Benzimidazoles Facilitated by Microwave Irradiation
Authors: Tseng, Chih-Chung
Tasi, Cheng-Hsun
Sun, Chung-Ming
Department of Applied Chemistry
Keywords: Benzimidazoles;bioactive heterocycles;fluorous synthesis;F-SPE;microwave chemistry
Issue Date: 1-Jun-2012
Abstract: A novel protocol for rapid assemble of benzimidazole framework has been demonstrated. This method incorporated with light fluorous-tag provides a convenient method for diversification of benzimidazoles and for easy purification via fluorous solid-phase extraction (F-SPE) in a parallel manner. The key transformation of this study involves in situ reduction of aromatic nitro compound, amide formation, cyclization and aromatization promoted by microwave irradiation in a one-pot fashion. The strategy is envisaged to be applied for the establishment of drug-like small molecule libraries for high throughput screening.
URI: http://hdl.handle.net/11536/16294
ISSN: 1386-2073
Volume: 15
Issue: 5
End Page: 411
Appears in Collections:Articles