標題: Design, simulation and experimental validation of a novel flexible neural probe for deep brain stimulation and multichannel recording
作者: Lai, Hsin-Yi
Liao, Lun-De
Lin, Chin-Teng
Hsu, Jui-Hsiang
He, Xin
Chen, You-Yin
Chang, Jyh-Yeong
Chen, Hui-Fen
Tsang, Siny
Shih, Yen-Yu I.
影像與生醫光電研究所
資訊工程學系
電機工程學系
腦科學研究中心
Institute of Imaging and Biomedical Photonics
Department of Computer Science
Department of Electrical and Computer Engineering
Brain Research Center
公開日期: 1-Jun-2012
摘要: An implantable micromachined neural probe with multichannel electrode arrays for both neural signal recording and electrical stimulation was designed, simulated and experimentally validated for deep brain stimulation (DBS) applications. The developed probe has a rough three-dimensional microstructure on the electrode surface to maximize the electrode-tissue contact area. The flexible, polyimide-based microelectrode arrays were each composed of a long shaft (14.9 mm in length) and 16 electrodes (5 mu m thick and with a diameter of 16 mu m). The ability of these arrays to record and stimulate specific areas in a rat brain was evaluated. Moreover, we have developed a finite element model (FEM) applied to an electric field to evaluate the volume of tissue activated (VTA) by DBS as a function of the stimulation parameters. The signal-to-noise ratio ranged from 4.4 to 5 over a 50 day recording period, indicating that the laboratory-designed neural probe is reliable and may be used successfully for long-term recordings. The somatosensory evoked potential (SSEP) obtained by thalamic stimulations and in vivo electrode-electrolyte interface impedance measurements was stable for 50 days and demonstrated that the neural probe is feasible for long-term stimulation. A strongly linear (positive correlation) relationship was observed among the simulated VTA, the absolute value of the SSEP during the 200 ms post-stimulus period (Sigma SSEP) and c-Fos expression, indicating that the simulated VTA has perfect sensitivity to predict the evoked responses (c-Fos expression). This laboratory-designed neural probe and its FEM simulation represent a simple, functionally effective technique for studying DBS and neural recordings in animal models.
URI: http://dx.doi.org/036001
http://hdl.handle.net/11536/16277
ISSN: 1741-2560
DOI: 036001
期刊: JOURNAL OF NEURAL ENGINEERING
Volume: 9
Issue: 3
結束頁: 
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