標題: Nano-hybrid carboxymethyl-hexanoyl chitosan modified with (3-aminopropyl)triethoxysilane for camptothecin delivery
作者: Hsiao, Meng-Hsuan
Tung, Tsan-Hua
Hsiao, Chi-Sheng
Liu, Dean-Mo
材料科學與工程學系
Department of Materials Science and Engineering
關鍵字: Chitosan;Silane;Amphiphiles;Self-assembly;Drug delivery systems
公開日期: 20-六月-2012
摘要: Silane-modified amphiphilic chitosan was synthesized by anchoring a silane coupling agent, (3-aminopropyl)triethoxysilane, to a novel amphiphilic carboxymethyl-hexanoyl chitosan (CHC). The chemical structure of this new organic-inorganic hybrid molecule was characterized by FTIR and C-13-, Si-29-nuclear magnetic resonance, while the structural evolution was examined using scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), and dynamic light scattering (DLS). Experimental results indicated a self-assembly behaviour of molecules into nanopartides with a stable polygonal geometry, consisting of ordered silane layers of 6 nm in thickness. The self-assembly property was found to be influenced by chemical composition and concentration of silane incorporated, while the size can be varied by the amount of anchored silane. It was also demonstrated that such vesicle exhibited excellent cytocompatibility and cellular internalization capability in ARPE-19 cell line, and presented well-controlled encapsulation and release profiles for (S)-(+)-camptothecin. These unique properties render it as a potential drug delivery nanosystem. (C) 2012 Elsevier Ltd. All rights reserved.
URI: http://hdl.handle.net/11536/16263
ISSN: 0144-8617
期刊: CARBOHYDRATE POLYMERS
Volume: 89
Issue: 2
結束頁: 632
顯示於類別:期刊論文


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