標題: Real-time Detection of alpha-Thrombin Binding to Single-Strand DNA Aptamers by a Highly Sensitive Si-Based Waveguide SPR Biosensor
作者: Huang, Chi-Chieh
Hsu, Hsin-Feng
Chen, Sz-Hau
Tsai, Kun-Yu
Huang, Yang-Tung
Lin, Chih-Sheng
Hsu, Shih-Hsin
電子工程學系及電子研究所
Department of Electronics Engineering and Institute of Electronics
關鍵字: SPR;surface plasmon resonance;sensor
公開日期: 2012
摘要: In this paper, real-time characterization of alpha-thrombin binding to single-strand DNA (ssDNA) aptamers by novel Si-based waveguide SPR biosensors has been investigated. The gold nanoparticles (AuNPs) modified with anti-thrombin antibodies were employed to bind with alpha-thrombin via strong antibody/antigen affinity for SPR signal amplification. The detection limit of 1 pM for alpha-thrombin detection was achieved.
URI: http://hdl.handle.net/11536/16228
http://dx.doi.org/83512R
ISBN: 978-0-8194-9027-8
ISSN: 0277-786X
DOI: 83512R
期刊: THIRD ASIA PACIFIC OPTICAL SENSORS CONFERENCE
Volume: 8351
顯示於類別:會議論文


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  1. 000304348500095.pdf