Title: Comparison of Gd-Bz-TTDA, Gd-EOB-DTPA, and Gd-BOPTA for dynamic MR imaging of the liver in rat models
Authors: Jaw, Twei-Shiun
Chen, Shih-Hsien
Wang, Yun-Ming
Hsu, Jui-Sheng
Kuo, Yu-Ting
Chiu, Yen-Yu
Tsai, Kun-Bow
Hsieh, Tsyh-Jyi
Liu, Gin-Chung
Department of Biological Science and Technology
Keywords: Magnetic resonance imaging;Contrast agents;Hepatobiliary
Issue Date: 1-Mar-2012
Abstract: To evaluate the competitive potential of a new lipophilic paramagnetic complex, Gd-Bz-TTDA [4-benzyl-3,6,10-tri (carboxymethyl)-3,6,10-triazado-decanedioic acid] compared with two other commercially available MR hepatobiliary contrast agents, gadobenate dimeglumine (Gd-BOPTA) and gadoxetic acid (Gd-EOB-DTPA), dynamic MR imaging studies were performed on normal and hepatocellular carcinoma (HCC) rat models using a 1.5-Tesla MR scanner. The results indicate that normal rats that were injected with 0.1 mmol/kg Gd-Bz-TTDA showed significantly more intense and persistent liver enhancement than those that were injected with the same dose of Gd-EOB-DTPA or Gd-BOPTA. All of these agents showed similar enhancement patterns in the implanted HCC. The liver-lesion contrast-to-noise ratios were higher and more persistent in rats that were injected with Gd-Bz-TTDA. These results indicate that Gd-Bz-TTDA is comparable with the commercially available hepatobiliary agents, Gd-EOB-DTPA and Gd-BOPTA, and can result in more intense and prolonged liver enhancement while still providing better liver-lesion discrimination. These results warrant further large-scale studies. Copyright (C) 2012, Elsevier Taiwan LLC. All rights reserved.
URI: http://hdl.handle.net/11536/16131
ISSN: 1607-551X
Volume: 28
Issue: 3
End Page: 130
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