標題: 7,7 ''-Dimethoxyagastisflavone-induced Apoptotic or Autophagic Cell Death in Different Cancer Cells
作者: Hwang, Chia-Hsiang
Lin, Yu-Ling
Liu, Yen-Ku
Chen, Chia-Hung
Wu, Hsin-Yi
Chang, Cheng-Chang
Chang, Chao-Yuan
Chang, Yu-Kuo
Chiu, Yi-Han
Liao, Kuang-Wen
Lai, Yiu-Kay
生物科技學系
分子醫學與生物工程研究所
Department of Biological Science and Technology
Institute of Molecular Medicine and Bioengineering
關鍵字: 7;7 ''-dimethoxyagastisflavone;biflavonoid;Taxus media cv;Hicksii;apoptosis;autophagy
公開日期: 1-四月-2012
摘要: 7,7''-Dimethoxyagastisflavone (DMGF), a biflavonoid isolated from the needles of Taxus X media cv. Hicksii, was evaluated for its antiproliferative and antineoplastic effects in three human cancer cell lines. Interestingly, DMGF caused cell death via different pathways in different cancer cells. DMGF induced apoptosis, activated caspase-3 activity and changed the mitochondrial membrane potential in HT-29 human colon cancer cells. However, the apoptotic pathway is not the major pathway involved in DMGF-induced cell death in A549 human lung cancer cells and HepG2 human hepatoma cells. Treatment with 3-MA, an inhibitor of autophagy, significantly decreased DMGF-induced cell death in HepG2 and A549 cells, but did not affect DMGF-induced cell death in HT-29 cells. Following DMGF treatment, the HepG2 cells increased expression of LC3B-II, a marker used to monitor autophagy in cells. Thus, DMGF induced apoptotic cell death in HT-29 cells, triggered both apoptotic and autophagic death in A549 cells and induced autophagic cell death in HepG2 cells. Copyright (C) 2011 John Wiley & Sons, Ltd.
URI: http://hdl.handle.net/11536/16103
ISSN: 0951-418X
期刊: PHYTOTHERAPY RESEARCH
Volume: 26
Issue: 4
結束頁: 528
顯示於類別:期刊論文


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