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dc.contributor.authorYang, Wen-Jenen_US
dc.contributor.authorYang, Chih-Shengen_US
dc.contributor.authorHuang, Chen-Jien_US
dc.contributor.authorChen, Ko-Shaoen_US
dc.contributor.authorLin, Shuen-Fuhen_US
dc.date.accessioned2014-12-08T15:22:35Z-
dc.date.available2014-12-08T15:22:35Z-
dc.date.issued2012-05-10en_US
dc.identifier.issn0141-0229en_US
dc.identifier.urihttp://hdl.handle.net/11536/15977-
dc.description.abstractBostrycin, a red antibacterial agent with tetrahydroanthraquinone structure, has been isolated from Nigrospora sp. No. 407. This study investigated the potential antibacterial and multifunctional properties of matrixes through immobilization of bostrycin on their surface for immobilization of protein and prevention of bacterial growth. Bostrycin was immobilized on nonwoven polypropylene (PP) fabric by a technique using glutaraldehyde and polyethyleneimine for the activation of the surface. Glucose oxidase immobilized on bostrycin-treated nonwoven PP fabric showed high activity. The immobilization process improved thermal stability of the enzymes. During repeated assay for 30 cycles, the enzyme activity dropped to only 70% of the initial activity. Both bostrycin-treated nonwoven PP fabric sample and subsequently immobilized glucose oxidase sample on the surface also still exhibited a bacteriostatic effect. This is the first study to show that bostrycin is a promising coupling agent for surface modification on matrix and its potential applications in protein immobilization and biomaterial-centered infection. Crown Copyright (C) 2012 Published by Elsevier Inc. All rights reserved.en_US
dc.language.isoen_USen_US
dc.subjectBostrycinen_US
dc.subjectCoupling agenten_US
dc.subjectSurface modificationen_US
dc.subjectProtein immobilizationen_US
dc.subjectBacteriostasisen_US
dc.titleBostrycin, a novel coupling agent for protein immobilization and prevention of biomaterial-centered infection produced by Nigrospora sp No. 407en_US
dc.typeArticleen_US
dc.identifier.journalENZYME AND MICROBIAL TECHNOLOGYen_US
dc.citation.volume50en_US
dc.citation.issue6-7en_US
dc.citation.epage287en_US
dc.contributor.department生物科技學系zh_TW
dc.contributor.departmentDepartment of Biological Science and Technologyen_US
dc.identifier.wosnumberWOS:000303955700003-
dc.citation.woscount1-
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