標題: Genetic copy number variants in myocardial infarction patients with hyperlipidemia
作者: Shia, Wei-Chung
Ku, Tien-Hsiung
Tsao, Yu-Ming
Hsia, Chien-Hsun
Chang, Yung-Ming
Huang, Ching-Hui
Chung, Yeh-Ching
Hsu, Shih-Lan
Liang, Kae-Woei
Hsu, Fang-Rong
資訊工程學系
Department of Computer Science
公開日期: 30-Nov-2011
摘要: Background: Cardiovascular disease is the chief cause of death in Taiwan and many countries, of which myocardial infarction (MI) is the most serious condition. Hyperlipidemia appears to be a significant cause of myocardial infarction, because it causes atherosclerosis directly. In recent years, copy number variation (CNV) has been analyzed in genomewide association studies of complex diseases. In this study, CNV was analyzed in blood samples and SNP arrays from 31 myocardial infarction patients with hyperlipidemia. Results: We identified seven CNV regions that were associated significantly with hyperlipidemia and myocardial infarction in our patients through multistage analysis (P<0.001), at 1p21.3, 1q31.2 (CDC73), 1q42.2 (DISC1), 3p21.31 (CDCP1), 10q11.21 (RET) 12p12.3 (PIK3C2G) and 16q23.3 (CDH13), respectively. In particular, the CNV region at 10q11.21 was examined by quantitative real-time PCR, the results of which were consistent with microarray findings. Conclusions: Our preliminary results constitute an alternative method of evaluating the relationship between CNV regions and cardiovascular disease. These susceptibility CNV regions may be used as biomarkers for early-stage diagnosis of hyperlipidemia and myocardial infarction, rendering them valuable for further research and discussion.
URI: http://dx.doi.org/S23
http://hdl.handle.net/11536/15900
ISSN: 1471-2164
DOI: S23
期刊: BMC GENOMICS
Volume: 12
Appears in Collections:Conferences Paper


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