Title: A Lipo-PEG-PEI complex for encapsulating curcumin that enhances its antitumor effects on curcumin-sensitive and curcumin-resistance cells
Authors: Lin, Yu-Ling
Liu, Yen-Ku
Tsai, Nu-Man
Hsieh, Jui-Hung
Chen, Chia-Hung
Lin, Ching-Min
Liao, Kuang-Wen
Department of Biological Science and Technology
Institute of Molecular Medicine and Bioengineering
Department of Electronics Engineering and Institute of Electronics
Keywords: Lipo-PEG-PEI complex;Curcumin;Cytotoxicity;Apoptosis;Antitumor
Issue Date: 1-Apr-2012
Abstract: A cationic liposome-PEG-PEI complex (LPPC) was used as a carrier for the encapsulation of hydrophobic curcumin to give curcumin/LPPC. Curcumin/LPPC had an average size less than 270 nm and a zeta potential of approximately 40 mV. The LPPC encapsulation efficiency for curcumin was about 45%. The authors found it surprising that the cytotoxic activity of the curcumin/LPPC was fivefold higher than curcumin when tested on curcumin-sensitive cells and 20-fold more active against curcumin-resistant cells. Curcumin/LPPC treatment caused a cell cycle arrest at G2/M phase, which rapidly resulted in apoptosis. The increased cytotoxic activity of curcumin/LPPC is likely attributable to its rapid accumulation in the cell. In vivo, administration of curcumin/LPPC inhibited about 60 - 90% of tumor growth in mice bearing CT-26 or B16F10 cells. These results demonstrate LPPC encapsulation technology is able to enhance the effects of antitumor drugs. Use of this technology may provide a new tool for cancer therapy, especially for drug-resistant cancer.
URI: http://dx.doi.org/10.1016/j.nano.2011.06.011
ISSN: 1549-9634
DOI: 10.1016/j.nano.2011.06.011
Volume: 8
Issue: 3
Begin Page: 318
End Page: 327
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