標題: Reduction-sensitive rapid degradable poly(urethane-urea)s based on cystine
作者: Lu, Haoxiang
Sun, Peiyu
Zheng, Zhen
Yao, Xiong
Wang, Xinling
Chang, Feng-Chih
應用化學系
Department of Applied Chemistry
關鍵字: Reduction-sensitive;Degradation;Disulfide bonds;Poly(urethane-urea)s;Glutathione;Dithiothreitol
公開日期: 1-四月-2012
摘要: Two kinds of novel reduction-sensitive rapid degradable poly(urethane-urea)s were synthesized and characterized based on a cystine derivative chain extender which provided active sites for reductive degradation. In vitro degradation study was carried out under physiological conditions mediated by glutathione and dithiothreitol respectively, and was assessed by H-1 NMR, GPC and SEM. The results indicated that the disulfide bonds in poly(urethane-urea)s were effectively cleaved while the structures of urethane groups and soft segments remained almost unaffected. Still, the rate and degree of reductive degradation could be controlled by the structures of the polymers. The influence of the poly(urethane-urea)s on human umbilical vein endothelial cells was investigated by WST-1 assay. The results indicated that the polymers sustained much higher cell viability than the controls. It is possible that the poly(urethane-urea)s can be potentially applied for temporary biomaterials such as wound closure devices, cell scaffolds and sophisticated drug delivery systems. (C) 2011 Elsevier Ltd. All rights reserved.
URI: http://dx.doi.org/10.1016/j.polymdegradstab.2011.12.023
http://hdl.handle.net/11536/15782
ISSN: 0141-3910
DOI: 10.1016/j.polymdegradstab.2011.12.023
期刊: POLYMER DEGRADATION AND STABILITY
Volume: 97
Issue: 4
起始頁: 661
結束頁: 669
顯示於類別:期刊論文


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