標題: Asymptotic limit in a cell differentiation model with consideration of transcription
作者: Friedman, Avner
Kao, Chiu-Yen
Shih, Chih-Wen
應用數學系
Department of Applied Mathematics
關鍵字: Cell differentiation;Th1/Th2 cells;Conservation law;Multistationary;Integro-differential equation;Transcription factors;mRNA
公開日期: 15-五月-2012
摘要: T cells of the immune system, upon maturation, differentiate into either Th1 or Th2 cells that have different functions. The decision to which cell type to differentiate depends on the concentrations of transcription factors T-bet (xi) and GATA-3 (x2). These factors are translated by the mRNA whose levels of expression, y(1) and y(2), depend, respectively, on xi and x2 in a nonlinear nonlocal way. The population density of T cells, phi(t, x(1), x(2), y(1), y(2)), satisfies a hyperbolic conservation law with coefficients depending nonlinearly and nonlocally on (t, x(1), x(2), y(1), y(2)). while the x(i), y(i) satisfy a system of ordinary differential equations. We study the long time behavior of and show, under some conditions on the parameters of the system of differential equations, that the gene expressions in the T-cell population aggregate at one, two or four points, which connect to various cell differentiation scenarios. (C) 2012 Elsevier Inc. All rights reserved.
URI: http://dx.doi.org/10.1016/j.jde.2012.02.006
http://hdl.handle.net/11536/15756
ISSN: 0022-0396
DOI: 10.1016/j.jde.2012.02.006
期刊: JOURNAL OF DIFFERENTIAL EQUATIONS
Volume: 252
Issue: 10
起始頁: 5679
結束頁: 5711
顯示於類別:期刊論文


文件中的檔案:

  1. 000301901100020.pdf