標題: The role of the sub-thalamic nucleus in the preparation of volitional movement termination in Parkinson's disease
作者: Hsu, Yi-Ting
Lai, Hsin-Yi
Chang, Yao-Chuan
Chiou, Shang-Ming
Lu, Ming-Kuei
Lin, Yu-Chin
Liu, Yen-Liang
Chen, Chiung-Chu
Huang, Hui-Chun
Chien, Ting-Fang
Lin, Shinn-Zong
Chen, You-Yin
Tsai, Chon-Haw
電機工程學系
Department of Electrical and Computer Engineering
關鍵字: Oscillation;Parkinson's disease;Sub-thalamic nucleus
公開日期: 1-一月-2012
摘要: The sub-thalamic nucleus (STN) is relevant to the preparation of movement ignition but its role in movement termination is uncertain. Fourteen patients with Parkinson's disease (PD) received local field potentials (LFPs) recording at the left STN on the fourth day after deep brain stimulation surgery. They performed phasic and tonic movements of the right wrist extensor. Movement onset (Mon) and movement offset (Moff) of the electromyographic activities were used as triggers to determine an eight-second LFPs epoch for time-frequency analysis. Movement-related power changes were assessed by repeated measures analysis of variance with within-subject factors of Event (Mon and Moff), Period (ten time periods for phasic movement and six time periods for tonic movement), and Frequency (alpha, low-beta, and high-beta). There was significant triple interaction in both the phasic and tonic movements. By post-hoc analysis, high-beta event-related desynchronization (ERD) appeared earlier (3 s prior to Mon) than those of low-beta and alpha for the Mon phasic movement. There was no alpha ERD for the Mon tonic movement. Alpha, low-beta, and high-beta ERD all appeared about 1 s prior to the Moff tonic movement. The current findings suggest that STN participates in the preparation of volitional movement termination but via a different mechanism from that in movement initiation. Unlike asynchronous ERD frequency bands present in movement initiation, a simultaneous ERD across wide frequency bands in STN may play a pivotal role in terminating volitional movement. (C) 2011 Elsevier Inc. All rights reserved.
URI: http://dx.doi.org/10.1016/j.expneurol.2011.10.013
http://hdl.handle.net/11536/15699
ISSN: 0014-4886
DOI: 10.1016/j.expneurol.2011.10.013
期刊: EXPERIMENTAL NEUROLOGY
Volume: 233
Issue: 1
起始頁: 253
結束頁: 263
顯示於類別:期刊論文


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  1. 000300123900029.pdf