標題: Bioactive TiO2 ultrathin film with worm-like mesoporosity for controlled drug delivery
作者: Chao, Chih-Shin
Liu, Kun-Ho
Tung, Wei-Lin
Chen, San-Yuan
Liu, Dean-Mo
Chang, Yen-Po
材料科學與工程學系
Department of Materials Science and Engineering
關鍵字: Mesoporous TiO2;Ultrathin film;Controlled drug release;Cytocompatibility;Bioactive coating
公開日期: 1-四月-2012
摘要: Ultrathin mesoporous TiO2 coatings with a wormhole-like architecture were synthesized using evaporation-induced self-assembly method. The morphological and chemical structures of TiO2 films were characterized using small-angle and large-angle X-ray diffraction, scanning electron microscopy (SEM), transmission electron microscopy (TEM) and Fourier transformed infrared spectrometry (FTIR). The films demonstrated a thickness of similar to 120 nm and open-porous nanostructure. By taking advantage of the tortuosity of the worm-like mesoporous architecture associated with the chemistry of the TiO2 film, a sustained drug release using ibuprofen and vancomycin as model molecules from the film was determined. Besides, adhesion behavior of osteoblast cells, together with an in vitro apaptitic formation substantiated the cytocompatibility and bioactivity of the mesoporous TiO2 films. Such combined bioactive and drug-releasing functions of the TiO2 films with worm-like mesoporosity ensure an improved therapeutic performance for potential applications included orthopedics, dentistry, and drug delivery. (C) 2011 Elsevier Inc. All rights reserved.
URI: http://dx.doi.org/10.1016/j.micromeso.2011.12.006
http://hdl.handle.net/11536/15548
ISSN: 1387-1811
DOI: 10.1016/j.micromeso.2011.12.006
期刊: MICROPOROUS AND MESOPOROUS MATERIALS
Volume: 152
Issue: 
起始頁: 58
結束頁: 63
顯示於類別:期刊論文


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