標題: Magnolol-Loaded Core-Shell Hydrogel Nanoparticles: Drug Release, Intracellular Uptake, and Controlled Cytotoxicity for the Inhibition of Migration of Vascular Smooth Muscle Cells
作者: Wang, Yen-Jen
Chien, Yin-Chih
Wu, Chieh-Hsi
Liu, Dean-Mo
材料科學與工程學系
Department of Materials Science and Engineering
關鍵字: core-shell hydrogel nanoparticle;magnolol-CHC nanoparticle;cell migration inhibition;cell uptake;magnolol;intracellular delivery
公開日期: 1-Nov-2011
摘要: Encapsulation and release behavior of a water-insoluble drug, magnolol, using a core shell polysaccharide-based nanoparticle, manipulating the cellular internalization and controlled cytotoidc effect of magnolol-loaded nanoparticles over the A10 vascular smooth muscle cells (VSMCs) was reported. A magnolol-polyvinylpyrrolidone (PVP) core phase was prepared, followed encapsulating by an amphiphilic carboxymethyl-hexanoyi chitosan (CHC) shell to form a magnolol-loaded core-shell hydrogel nanoparticles (termed magnolol-CHC nanoparticles). The resulting magnolol-CHC nanopartides were employed for evaluation of drug release and controlled cytotoxic inhibition of VSMCs migration in vitro. A sustained release of the magnolol from the nanoparticles was determined. The magnolol-CHC nanoparticles exhibited outstanding cellular uptake efficiency, and under a cytotoxic evaluation, an increased antiproliferative effect and effective inhibition of VSMC migration as a result of efficient intracellular delivery of the encapsulated magnolol in comparison to free magnolol was achieved. We then envision a potential intracellular medication strategy with improved biological and therapeutic efficacy using the magnolol-CHC nanoparticles illustrated in this work.
URI: http://dx.doi.org/10.1021/mp200257y
http://hdl.handle.net/11536/15377
ISSN: 1543-8384
DOI: 10.1021/mp200257y
期刊: MOLECULAR PHARMACEUTICS
Volume: 8
Issue: 6
起始頁: 2339
結束頁: 2349
Appears in Collections:Articles


Files in This Item:

  1. 000297537300036.pdf