標題: Pepsin-inspired polyurethanes containing a tyrosine-fumaric acid-tyrosine segment
作者: Lu, Haoxiang
Wang, Wei
Zheng, Zhen
Sun, Peiyu
Wang, Xinling
Chang, Feng-Chih
應用化學系
Department of Applied Chemistry
公開日期: 2012
摘要: Two kinds of novel peptide mimetic pepsin-inspired degradable polyurethanes were synthesized and characterized. A synthetic pseudo tripeptide acted as chain extender and provided active sites for pepsin biodegradation. In vitro degradation behavior was investigated in simulated gastric fluid containing pepsin, and assessed by H-1 NMR, mass loss and SEM. The results indicated that the pseudo peptide bonds in polyurethanes were effectively digested by the action of pepsin. Furthermore, the rate and degree of pepsin-inspired polyurethanes in simulated gastric fluid containing pepsin could be controlled by alteration of the soft segments and activity of pepsin. The influence of the polymers on human umbilical vein endothelial cells was evaluated by WST-1 assay. The results indicated that the polymers sustained much higher cell viability than the controls.
URI: http://hdl.handle.net/11536/15311
http://dx.doi.org/10.1039/c2py00481j
ISSN: 1759-9954
DOI: 10.1039/c2py00481j
期刊: POLYMER CHEMISTRY
Volume: 3
Issue: 2
起始頁: 498
結束頁: 503
顯示於類別:期刊論文


文件中的檔案:

  1. 000298991200034.pdf