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dc.contributor.authorLam, Charlene L. M.en_US
dc.contributor.authorLiu, Ho-Lingen_US
dc.contributor.authorHuang, Chih-Maoen_US
dc.contributor.authorWai, Yau-Yauen_US
dc.contributor.authorLee, Shwu-Huaen_US
dc.contributor.authorYiend, Jennyen_US
dc.contributor.authorLin, Cheminen_US
dc.contributor.authorLee, Tatia M. C.en_US
dc.date.accessioned2019-10-05T00:08:48Z-
dc.date.available2019-10-05T00:08:48Z-
dc.date.issued2019-10-01en_US
dc.identifier.issn1931-7557en_US
dc.identifier.urihttp://dx.doi.org/10.1007/s11682-018-9940-yen_US
dc.identifier.urihttp://hdl.handle.net/11536/152881-
dc.description.abstractLate-life depression is common among older adults. Although white-matter abnormality is highly implicated, the extent to which the corticospinal tract is associated with the pathophysiology of late-life depression is unclear. The current study aims to investigate the white-matter structural integrity of the corticospinal tract and determine its cognitive and functional correlates in older adults with late-life depression. Twenty-eight older adults with clinical depression and 23 healthy age-matched older adults participated in the study. The white matter volume and the white matter hyperintensities (WMHs) of the corticospinal tract, as well as the global WMHs, were measured. Psychomotor processing speed, severity of depression, perceived levels of energy and physical functioning were measured to examine the relationships among the correlates in the depressed participants. The right corticospinal tract volume was significantly higher in depressed older adults relative to healthy controls. Moreover, the right corticospinal tract volume was significantly associated with the overall severity of depression and accounted for 17% of its variance. It further attenuated the relationship between the severity of depression and perceived levels of energy. Our findings suggested that higher volume in the right corticospinal tract is implicated in LLD and may relate to lower perceived levels of energy experienced by older adults with depression.en_US
dc.language.isoen_USen_US
dc.subjectLate-life depressionen_US
dc.subjectCorticospinal tracten_US
dc.subjectProcessing speeden_US
dc.subjectWhite matter hyperintensitiesen_US
dc.subjectWhite matteren_US
dc.titleThe neural correlates of perceived energy levels in older adults with late-life depressionen_US
dc.typeArticleen_US
dc.identifier.doi10.1007/s11682-018-9940-yen_US
dc.identifier.journalBRAIN IMAGING AND BEHAVIORen_US
dc.citation.volume13en_US
dc.citation.issue5en_US
dc.citation.spage1397en_US
dc.citation.epage1405en_US
dc.contributor.department生物科技學院zh_TW
dc.contributor.departmentCollege of Biological Science and Technologyen_US
dc.identifier.wosnumberWOS:000484959700020en_US
dc.citation.woscount0en_US
Appears in Collections:Articles