標題: Structural alphabet motif discovery and a structural motif database
作者: Ku, Shih-Yen
Hu, Yuh-Jyh
分子醫學與生物工程研究所
資訊工程學系
Institute of Molecular Medicine and Bioengineering
Department of Computer Science
關鍵字: Protein structures;Structural alphabets;Structural motifs;Sequence motifs;Motif-finding tools
公開日期: 1-一月-2012
摘要: This study proposes a general framework for structural motif discovery. The framework is based on a modular design in which the system components can be modified or replaced independently to increase its applicability to various studies. It is a two-stage approach that first converts protein 3D structures into structural alphabet sequences, and then applies a sequence motif-finding tool to these sequences to detect conserved motifs. We named the structural motif database we built the SA-Motifbase, which provides the structural information conserved at different hierarchical levels in SCOP. For each motif, SA-Motifbase presents its 3D view; alphabet letter preference; alphabet letter frequency distribution; and the significance. SA-Motifbase is available at http://bioinfo.cis.nctu.edu.tw/samotifbase/. (C) 2011 Elsevier Ltd. All rights reserved.
URI: http://dx.doi.org/10.1016/j.compbiomed.2011.10.013
http://hdl.handle.net/11536/15284
ISSN: 0010-4825
DOI: 10.1016/j.compbiomed.2011.10.013
期刊: COMPUTERS IN BIOLOGY AND MEDICINE
Volume: 42
Issue: 1
起始頁: 93
結束頁: 105
顯示於類別:期刊論文


文件中的檔案:

  1. 000299667500011.pdf