|標題:||Nickel Carbodicarbene Catalyzes Kumada Cross-Coupling of Aryl Ethers with Grignard Reagents through C-O Bond Activation|
Yap, Glenn P. A.
Department of Applied Chemistry
|關鍵字:||Carbene ligands;C-O Cleavage;Cross-coupling;Nickel;Synthetic methods|
|摘要:||The development of a cross-coupling reaction protocol between aryl ethers and Grignard reagents catalyzed by carbodicarbene (CDC) nickel complexes to afford biaryl compounds through C-O cleavage is reported. Aromatic substrates featuring a broad range of electron neutral, donating, or withdrawing groups are introduced at the desired position. The method has proven effective over a wide range of naphthyl methyl ethers, anisoles, and Grignard reagents. The robustness of the protocol is validated by performing multiple cleavage reactions, gram scale synthesis, and arylation of a dimethoxy esterdiol derivative.|
|期刊:||EUROPEAN JOURNAL OF INORGANIC CHEMISTRY|
|Appears in Collections:||Articles|