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dc.contributor.authorTsai, Pei-Ien_US
dc.contributor.authorChen, Chih-Yuen_US
dc.contributor.authorHuang, Shu-Weien_US
dc.contributor.authorYang, Kuo-Yien_US
dc.contributor.authorLin, Tzu-Hungen_US
dc.contributor.authorChen, San-Yuanen_US
dc.contributor.authorSun, Jui-Shengen_US
dc.date.accessioned2019-04-02T05:59:27Z-
dc.date.available2019-04-02T05:59:27Z-
dc.date.issued2018-10-01en_US
dc.identifier.issn0736-0266en_US
dc.identifier.urihttp://dx.doi.org/10.1002/jor.24037en_US
dc.identifier.urihttp://hdl.handle.net/11536/148420-
dc.description.abstractThe interference screw is a widely used fixation device in the anterior cruciate ligament (ACL) reconstruction surgeries. Despite the generally satisfactory results, problems of using interference screws were reported. By using additive manufacturing (AM) technology, we developed an innovative titanium alloy (Ti6Al4V) interference screw with rough surface and inter-connected porous structure designs to improve the bone-tendon fixation. An innovative Ti6Al4V interference screws were manufactured by AM technology. In vitro mechanical tests were performed to validate its mechanical properties. Twenty-seven New Zealand white rabbits were randomly divided into control and AM screw groups for biomechanical analyses and histological analysis at 4, 8, and 12 weeks postoperatively; while micro-CT analysis was performed at 12 weeks postoperatively. The biomechanical tests showed that the ultimate failure load in the AM interference screw group was significantly higher than that in the control group at all tested periods. These results were also compatible with the findings of micro-CT and histological analyses. In micro-CT analysis, the bone-screw gap was larger in the control group; while for the additive manufactured screw, the screw and bone growth was in close contact. In histological study, the bone-screw gaps were wider in the control group and were almost invisible in the AM screw group. The innovative AM interference screws with surface roughness and inter-connected porous architectures demonstrated better bone-tendon-implant integration, and resulted in stronger biomechanical characteristics when compared to traditional screws. These advantages can be transferred to future interference screw designs to improve their clinical performance. The AM interference screw could improve graft fixation and eventually result in better biomechanical performance of the bone-tendon-screw construct. The innovative AM interference screws can be transferred to future interference screw designs to improve the performance of implants. (c) 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:2633-2640, 2018.en_US
dc.language.isoen_USen_US
dc.subjectbone-tendon interfaceen_US
dc.subjectanimal studiesen_US
dc.subjectinterference screwen_US
dc.subjectadditive manufacturingen_US
dc.subjectTi-alloy implantsen_US
dc.titleImprovement of bone-tendon fixation by porous titanium interference screw: A rabbit animal modelen_US
dc.typeArticleen_US
dc.identifier.doi10.1002/jor.24037en_US
dc.identifier.journalJOURNAL OF ORTHOPAEDIC RESEARCHen_US
dc.citation.volume36en_US
dc.citation.spage2633en_US
dc.citation.epage2640en_US
dc.contributor.department材料科學與工程學系zh_TW
dc.contributor.departmentDepartment of Materials Science and Engineeringen_US
dc.identifier.wosnumberWOS:000449527800007en_US
dc.citation.woscount1en_US
Appears in Collections:Articles