標題: Effect of Uveitis on the Development of Keratopathy: A Population-Based Cohort Study
作者: Nien, Chan-Wei
Lee, Chia-Yi
Chao, Shih-Chun
Hsu, Hung-Jui
Huang, Jing-Yang
Yeh, Chao-Bin
Chen, Hung-Chi
Sun, Chi-Chin
Lin, Hung-Yu
Yang, Shun-Fa
電機工程學系
Department of Electrical and Computer Engineering
關鍵字: uveitis;keratopathy;cornea;population-based
公開日期: 1-Oct-2018
摘要: PURPOSE. The purpose of this study was to evaluate the effect of uveitis on the development of various keratopathies via the use of the National Health Insurance Research Database (NHIRD) in Taiwan. METHODS. Approximately 1 million patients were randomly sampled from the registry of the NHIRD. Patients diagnosed with uveitis by ophthalmologists were enrolled in the study group after exclusion. Each individual in the study group was age and sex matched to four nonuveitis individuals who serve as the control group. In addition to keratopathy, other possible risk factors and medications were included in the multivariate model, and the effects of different subtypes of uveitis for developing keratopathies were also analyzed. RESULTS. A total of 4773 uveitis patients (2662 male and 2111 female) and 19,092 non-uveitis patients (10,648 male and 8444 female) were enrolled. There were 406 events of keratopathy in the study group, and another 764 events occurred in the control group. A higher incidence rate was found in the study group after adjustment (adjusted hazard ratio [aHR]: 1.772), with a greater cumulative probability (P < 0.0001). For the subgroup analysis, anterior uveitis (aHR = 1.765) and panuveitis (aHR = 3.386) increased the risk of developing keratopathies. Moreover, male sex was associated with a higher aHR than female sex for developing keratopathies in the study group. CONCLUSIONS. The presence of uveitis significantly elevates the risk for developing keratopathy.
URI: http://dx.doi.org/10.1167/iovs.18-25039
http://hdl.handle.net/11536/148415
ISSN: 0146-0404
DOI: 10.1167/iovs.18-25039
期刊: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
Volume: 59
起始頁: 5053
結束頁: 5059
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