標題: Noninvasive Glucose Monitoring with a Contact Lens and Smartphone
作者: Lin, You-Rong
Hung, Chin-Chi
Chiu, Hsien-Yi
Chang, Po-Han
Li, Bor-Ran
Cheng, Sheng-Jen
Yang, Jia-Wei
Lin, Shien-Fong
Chen, Guan-Yu
交大名義發表
生物科技學系
應用化學系
National Chiao Tung University
Department of Biological Science and Technology
Department of Applied Chemistry
關鍵字: noninvasive;glucose monitoring;contact lens;smartphone;image detection
公開日期: 1-Oct-2018
摘要: Diabetes has become a chronic metabolic disorder, and the growing diabetes population makes medical care more important. We investigated using a portable and noninvasive contact lens as an ideal sensor for diabetes patients whose tear fluid contains glucose. The key feature is the reversible covalent interaction between boronic acid and glucose, which can provide a noninvasive glucose sensor for diabetes patients. We present a phenylboronic acid (PBA)-based HEMA contact lens that exhibits a reversible swelling/shrinking effect to change its thickness. The difference in thickness can be detected in a picture taken with a smartphone and analyzed using software. Our novel technique offers the following capabilities: (i) non-enzymatic and continuous glucose detection with the contact lens; (ii) no need for an embedded circuit and power source for the glucose sensor; and (iii) the use of a smartphone to detect the change in thickness of the contact lens with no need for additional photo-sensors. This technique is promising for a noninvasive measurement of the glucose level and simple implementation of glucose sensing with a smartphone.
URI: http://dx.doi.org/10.3390/s18103208
http://hdl.handle.net/11536/148383
ISSN: 1424-8220
DOI: 10.3390/s18103208
期刊: SENSORS
Volume: 18
Appears in Collections:Articles


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