標題: Fungal immunomodulatory protein-fve could modulate airway remodel through by affect IL17 cytokine
作者: Lee, Yu-Tzu
Wu, Chia-Ta
Sun, Hai-Lun
Ko, Jiunn-Liang
Lue, Ko-Haung
生物科技學院
College of Biological Science and Technology
關鍵字: Asthma;Airway remodeling;Collagen deposition;FIP-fve;IL-17;IL-22
公開日期: 1-Oct-2018
摘要: Background: Asthma is one of the most common allergic diseases. Our previous studies have reported that FIP-fve in acute allergic mouse model can reduce inflammation, improve the balance of the Th1/Th2 system. However, the effects of reducing airway remodeling on FIP-fve is still unknown. Objective: We hypothesized that orally administrated FIP-fve should be able to reduce airway remodeling in chronic allergic models. Methods: The chronic asthma animal model was established with 6-8 weeks female Balb/c mice. After intranasal challenges with OVA, the airway inflammation and AHR were determined by a BUXCO system. BALF was analyzed with Liu's stain and ELISA assay. Lung histopathologic changes and Collagen deposition were assayed with H&E, Masson's trichrome and IHC stain. Results: FIP-fve significantly decreased the number of infiltrating inflammatory cells and Th2 cytokines and increased Th1 cytokines in BALF and serum compared with the OVA sensitized mice. FIP-fve had a better effect than corticosteroid could reduce infiltrating cells in lung especially neutrophils and eosinophils. We also found that the oral FIP-fve group suppressed IL-17 and enhanced IL-22 in the serum and BALF. In addition, oral FIP-fve decreased MMP9 expression, collagen expression and airway remodeling in lung tissues. Conclusion: FIP-fve had anti-inflammatory effects on OVA-induced airway inflammation and an effect to inhibited Th17 cells to reduced airway remodeling and collagen expression. Moreover, FIP-fve might be a potential alternative therapy for allergic airway diseases. Copyright (C) 2017, Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC. This is an open access article under the CC BY-NC-ND license.
URI: http://dx.doi.org/10.1016/j.jmii.2017.06.008
http://hdl.handle.net/11536/148222
ISSN: 1684-1182
DOI: 10.1016/j.jmii.2017.06.008
期刊: JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
Volume: 51
起始頁: 598
結束頁: 607
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