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dc.contributor.authorLee, Chia-Yien_US
dc.contributor.authorChen, Hung-Chien_US
dc.contributor.authorLin, Hui-Wenen_US
dc.contributor.authorHuang, Jing-Yangen_US
dc.contributor.authorChao, Shih-Chunen_US
dc.contributor.authorYeh, Chao-Binen_US
dc.contributor.authorLin, Hung-Yuen_US
dc.contributor.authorYang, Shun-Faen_US
dc.date.accessioned2019-04-02T06:00:52Z-
dc.date.available2019-04-02T06:00:52Z-
dc.date.issued2018-09-01en_US
dc.identifier.issn0007-1161en_US
dc.identifier.urihttp://dx.doi.org/10.1136/bjophthalmol-2017-310975en_US
dc.identifier.urihttp://hdl.handle.net/11536/148172-
dc.description.abstractBackground To investigate the relationship between blepharitis and metabolic syndrome (MetS) by using the Longitudinal Health Insurance Database (LHID) of Taiwan. Methods This retrospective cohort study was conducted using data collected from the LHID for the period from 2009 to 2013. This study enrolled patients who received a diagnosis of blepharitis according to the International Classification of Diseases, Ninth Revision, diagnostic code. The exclusion criteria were legal blindness, eyeball removal, ocular tumours prior to the diagnosis of blepharitis, and patients diagnosed with blepharitis and initiated antibiotic treatment concurrently. An age-matched, gender-matched and disease-matched population without blepharitis served as the control group. Multivariate analysis with a multiple Cox regression model was applied to analyse the data. Results In this study, a total of 10 093 patients with blepharitis were included in the study group, and another 40 372 participants without blepharitis were included in the control group. Conditional logistic regression revealed a higher cumulative probability of hyperlipidaemia and coronary arterial disease. After adjustment, patients with blepharitis had a higher probability of developing new MetS than controls. According to subgroup analysis, hyperlipidaemia and coronary artery diseases were significantly correlated with the prior development of blepharitis. However, hypertension and diabetes mellitus and insulin resistance showed no correlation with blepharitis. Conclusion Blepharitis is significantly related to MetS and can serve as an early sign of MetS. Additional studies should examine the relationship between blepharitis and MetS in terms of severity.en_US
dc.language.isoen_USen_US
dc.titleBlepharitis as an early sign of metabolic syndrome: a nationwide population-based studyen_US
dc.typeArticleen_US
dc.identifier.doi10.1136/bjophthalmol-2017-310975en_US
dc.identifier.journalBRITISH JOURNAL OF OPHTHALMOLOGYen_US
dc.citation.volume102en_US
dc.citation.spage1283en_US
dc.citation.epage1287en_US
dc.contributor.department電機工程學系zh_TW
dc.contributor.departmentDepartment of Electrical and Computer Engineeringen_US
dc.identifier.wosnumberWOS:000445109700019en_US
dc.citation.woscount0en_US
Appears in Collections:Articles