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dc.contributor.authorHuang, Ching-Huien_US
dc.contributor.authorChang, Chia-Chuen_US
dc.contributor.authorKuo, Chen-Lingen_US
dc.contributor.authorHuang, Ching-Shanen_US
dc.contributor.authorChiu, Tzai-Wenen_US
dc.contributor.authorLin, Chih-Shengen_US
dc.contributor.authorLiu, Chin-Sanen_US
dc.date.accessioned2019-04-03T06:43:34Z-
dc.date.available2019-04-03T06:43:34Z-
dc.date.issued2014-08-06en_US
dc.identifier.issn1932-6203en_US
dc.identifier.urihttp://dx.doi.org/10.1371/journal.pone.0104495en_US
dc.identifier.urihttp://hdl.handle.net/11536/147766-
dc.description.abstractObjective: Anemia is associated with high mortality and poor prognosis after acute coronary syndrome (A(S). Increased red cell distribution width (RDW) is a strong independent predictor for adverse outcomes in ACS. The common underlying mechanism for anemia and increased RDW value is iron deficiency. It is not clear whether serum iron deficiency without anemia affects left ventricular (LV) performance after primary angioplasty for acute myocardial infarction (AMI). We investigated the prognostic value of serum iron concentration on LV ejection fraction (EF) at 6 months and its relationship to thrombolysis in myocardial infarction (TIMI) risk score in post MI patients. Methods: We recruited 55 patients who were scheduled to undergo primary coronary balloon angioplasty after AM I and 54 age- and sex-matched volunteers. Serum iron concentration and interleukin-6 levels were measured before primary angioplasty. LVEF was measured by echocardiography at baseline and after 6 months. TIMI risk score was calculated for risk stratification. Results: Serum iron concentration was significantly lower in those in whom LVEF had not improved >= 10% from baseline (52.7 +/- 24.1 versus 80.8 +/- 50.8 mu g/dl, P = 0.016) regardless of hemoglobin level, and was significantly lower in the AMI group than in the control group (62.5 +/- 37.7 versus 103.0 +/- 38.1 mu g/dl, P<0.001). Trend analysis revealed that serum iron concentration decreased as TIMI risk score increased (P = 0.002). In addition, lower serum iron concentrations were associated with higher levels of inflammatory markers. Multiple linear regression showed that baseline serum iron concentration can predict LV systolic function 6 months after primary angioplasty for AMI even after adjusting for traditional prognostic factors. Conclusion: Hypoferremia is not only a marker of inflammation but also a potential prognostic factor for LV systolic function after revascularization therapy for AMI, and may be a novel biomarker for therapeutic intervention.en_US
dc.language.isoen_USen_US
dc.titleSerum Iron Concentration, but Not Hemoglobin, Correlates with TIMI Risk Score and 6-Month Left Ventricular Performance after Primary Angioplasty for Acute Myocardial Infarctionen_US
dc.typeArticleen_US
dc.identifier.doi10.1371/journal.pone.0104495en_US
dc.identifier.journalPLOS ONEen_US
dc.citation.volume9en_US
dc.citation.issue8en_US
dc.citation.spage0en_US
dc.citation.epage0en_US
dc.contributor.department生物科技學系zh_TW
dc.contributor.departmentDepartment of Biological Science and Technologyen_US
dc.identifier.wosnumberWOS:000339995100079en_US
dc.citation.woscount10en_US
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