Title: Desymmetrization of 2,4,5,6-Tetra-O-benzyl-D-myo-inositol for the Synthesis of Mycothiol
Authors: Chung, Chuan-Chung
Zulueta, Medel Manuel L.
Padiyar, Laxmansingh T.
Hung, Shang-Cheng
Department of Applied Chemistry
Issue Date: 21-Oct-2011
Abstract: An efficient chemical synthesis of mycothiol Involving the regioselective ketopinyl desymmetrization of 2,4,5,6-tetrabenzylated D-myo-inositol as the key step Is described. Together with a highly alpha-stereoselective D-glucosaminylation, the whole procedure was accomplished in eight steps with an overall yield of 40%.
URI: http://dx.doi.org/10.1021/ol202218n
ISSN: 1523-7060
DOI: 10.1021/ol202218n
Volume: 13
Issue: 20
Begin Page: 5496
End Page: 5499
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