標題: RNAcentral: A vision for an international database of RNA sequences
作者: Bateman, Alex
Agrawal, Shipra
Birney, Ewan
Bruford, Elspeth A.
Bujnicki, Janusz M.
Cochrane, Guy
Cole, James R.
Dinger, Marcel E.
Enright, Anton J.
Gardner, Paul P.
Gautheret, Daniel
Griffiths-Jones, Sam
Harrow, Jen
Herrero, Javier
Holmes, Ian H.
Huang, Hsien-Da
Kelly, Krystyna A.
Kersey, Paul
Kozomara, Ana
Lowe, Todd M.
Marz, Manja
Moxon, Simon
Pruitt, Kim D.
Samuelsson, Tore
Stadler, Peter F.
Vilella, Albert J.
Vogel, Jan-Hinnerk
Williams, Kelly P.
Wright, Mathew W.
Zwieb, Christian
生物資訊及系統生物研究所
Institude of Bioinformatics and Systems Biology
關鍵字: sequence database;federation;noncoding RNA
公開日期: 1-十一月-2011
摘要: During the last decade there has been a great increase in the number of noncoding RNA genes identified, including new classes such as microRNAs and piRNAs. There is also a large growth in the amount of experimental characterization of these RNA components. Despite this growth in information, it is still difficult for researchers to access RNA data, because key data resources for noncoding RNAs have not yet been created. The most pressing omission is the lack of a comprehensive RNA sequence database, much like UniProt, which provides a comprehensive set of protein knowledge. In this article we propose the creation of a new open public resource that we term RNAcentral, which will contain a comprehensive collection of RNA sequences and fill an important gap in the provision of biomedical databases. We envision RNA researchers from all over the world joining a federated RNAcentral network, contributing specialized knowledge and databases. RNAcentral would centralize key data that are currently held across a variety of databases, allowing researchers instant access to a single, unified resource. This resource would facilitate the next generation of RNA research and help drive further discoveries, including those that improve food production and human and animal health. We encourage additional RNA database resources and research groups to join this effort. We aim to obtain international network funding to further this endeavor.
URI: http://dx.doi.org/10.1261/rna.2750811
http://hdl.handle.net/11536/14698
ISSN: 1355-8382
DOI: 10.1261/rna.2750811
期刊: RNA-A PUBLICATION OF THE RNA SOCIETY
Volume: 17
Issue: 11
起始頁: 1941
結束頁: 1946
顯示於類別:期刊論文


文件中的檔案:

  1. 000296492400001.pdf